Exact(1)
Using the FI/LE ratio as an indicator of healthy aging and a predictor of demands on health and social care systems, the higher ratio for the Beijing urban population compared with Hong Kong suggests that population ageing in China is projected to be accompanied by increasing frailty, and that there is a need to focus on measures to reduce the frailty burden.
Similar(59)
Using a comparison group from the same population increases the homogeneity of the sample and ensures conservative findings (that is, a bias toward the null), particularly if there is a healthy survivor effect that reduces the frailty of those who survived among the infection groups versus those who survived among the controls.
Broadly speaking, interventions for the frailty syndrome should aim to 1) prevent, delay, reverse, or reduce the severity of frailty, and 2) prevent or reduce adverse health outcomes in those whose frailty is not reversible.
In other words, the activities in people's daily lives are not sufficiently intense to reduce the progression of frailty.
Previous studies have verified that bodily activities or resistance training reduce the occurrence of frailty and provide positive enhancements for the health of elderly people [ 39– 44].
Despite this cost, to the best of our knowledge, there has been no research to date examining the effectiveness of an intervention designed to reduce the transition to frailty among pre-frail older people.
Characterising population subgroups at risk of frailty and relationships between frailty, social circumstances, depressive symptoms, cognition and other health-related factors will help identify modifiable intervention targets which may reduce the burden of frailty for individuals and help give directions for public health policy [ 5].
To reduce the heterogeneity in reporting frailty, standardization of cut points for the phenotype criteria may be the best viable option for making comparisons across culturally, economically, and socially diverse populations such as those found in SHARE countries more meaningful, especially since the association with adverse health outcomes has been validated in many countries.
However, more research is needed to address how medical expenditures and facilities can be best utilised for patients at the end of their life and to reduce the escalating burden of frailty for family care givers in the context of China's unique healthcare structure.
Although this has begun to reduce the stock of unsold new homes, the frailty of demand means that supply still vastly outweighs sales.
Taken together, these data demonstrate that periodic treatment with senolytics is sufficient to reduce the burden of senescence markers, reduce frailty, and extend healthspan significantly.
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Justyna Jupowicz-Kozak
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