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However, some limitations associated with the measurement of informed choice in this study reduce the certainty of the conclusions that can be drawn.
The summative risks of chemotherapy-induced infertility (say, 20%), early metastatic relapse (say, 20%) or marital problems (say, 10%) might be expected to reduce the certainty of having another baby, keeping in mind that the duration of any adjuvant hormonal therapy is likely to be five years or longer.
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"It would erode confidence in our economy and reduce the certainty for small businesses.
Since we have little guidance on how such a misfire could happen or in what direction it would affect the poll results, we try to adjust for the chance of misfires by adding completely random noise to the model that reduces the certainty of the estimates.
There is a risk that patients with transient confusion could be falsely classified as having suspected or evident cognitive impairment, which also reduces the certainty of our conclusions.
IND was defined as an area of atypical surface and crypt epithelium suggestive of possible dysplasia, but with interpretation limited due to associated inflammation (raising the possibility of reactive atypia), ulceration, or technical issues, including lack of surface epithelium, marked cautery effect, or tangential sectioning, reducing the certainty of the evaluation of the biopsy.
18 21 In our study, there were a small number of studies where the researchers considered that the methodological problems (eg, recruiting sufficient sample) limited the opportunity to generate significant intervention effects or reduced the certainty of their findings (ie, inability to include randomisation); therefore, these studies did not have policy and practice impacts.
In reducing the certainties of his parishioners, William believes, science has left them deep in explanatory failure.
By reducing the certainty level to 85% in the NOS triage approach the proportion of DXAs saved remained high whilst preserving an acceptably low misclassification rate.
Baseline QOL data were not available for all patients in our cohort, which reduces the statistical certainty of our analyses.
So we systematically reduce our estimation of the certainty of the win for contests in which the undecided share of voters is larger than the margin between the candidates.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com