IL-6 was reduced systemically in the serum by both treatments; however, this reduction was not apparent in washouts of joints.
As mentioned above, although many acknowledge that Dodd-Frank has been successful in reducing systemic risk in the financial system, most agree that Congress and regulators cast a very wide net in deciding which firms were systemically important.
To reduce metastases, systemically active cytotoxic chemotherapy with or without biological agents is clearly required.
To guard against ischemic brain injury, tissue metabolic demand is reduced by systemically cooling the patient prior to circulatory arrest.
These results show that two doses of MC-TG prolong MDSC depletion in the blood, that lower doses of MC-TG were effective at reducing MDSCs systemically and locally, and that the magnitude of MDSC depletion was dose dependent, with 10 mg/kg being the most effective dose.
Manipulations that systemically reduce insulin/IGF signaling and extend Drosophila lifespan often induce metabolic and stress-resistant phenotypes.
Finally, it has been suggested that a five week dietary 'run-in' period is required to systemically reduce folate levels in mice [ 49], and data from rats suggest that at least 4 weeks may be required to deplete selenium [ 50].
Despite the inhibition of arenavirus replication in cell culture model systems, MY-24 did not reduce the viral burden systemically nor in the various hamster or mouse tissues examined.
If moral hazard does not cause systemically important firms to engage in excessively risky behavior, then this approach would merely reduce the number of systemically important firms that can engage in such behavior.
In sum, GE Capital's travels through the FSOC designation process underscore that the ultimate goal is to reduce the number of systemically important financial institutions, not to increase the Fed's regulatory reach and regulatory burden.
