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α2-Adrenoceptor agonists also have application as antihypertensive drugs, based on their ability to reduce sympathetic outflow.
The central treatment completely ablated the developmental rise in brain norepinephrine and dopamine and had little effect on peripheral norepinephrine levels, but has been shown to reduce sympathetic tone.
The inhibition of NKCC1 in these hypertensive animals acts to reduce sympathetic vasomotor tone and lower their heart rates (51).
Early interventions aiming to reduce sympathetic overactivity in patients with low BRS might delay the development of hypertension.
Since these drugs reduce bronchoconstriction and hyperinflation, it is conceivable that inhaled β2-agonists reduce sympathetic activation in COPD.
On the other hand, there are several previous studies suggesting that statins can reduce sympathetic activity, thereby resulting in pulse rate reduction [ 46, 47].
Similar(47)
Reduced sympathetic activity accounts for the reduced frequencies of hypertension, type 2 diabetes and dyslipidaemia in untreated PD patients [ 89].
Another postulated cause of IMCL and IHCL accumulation is not lipid shunting from adipose depots, but rather de novo lipogenesis along with a reduction of β-oxidation of fat 86 due to low aerobic capacity, a reduced number or malfunction of mitochondria, or reduced sympathetic tone.
Reduced sympathetic innervation after alteration of target cell neurotransmitter phenotype in transgenic mice.
Reduced sympathetic skin response in the isolated spinal cord of subjects with spinal cord injury.
As the Kansas City doctors wrote, "Frequent physical activity reduces sympathetic activity through many indirect mechanisms, including weight loss, reduced anxiety and depression, improved insulin sensitivity and as an aid in smoking cessation efforts".
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