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In the case of employers, countries could consider imposing restrictions on the dismissal of workers in order to reduce substitution effects.
In the first case, the two main goals are to reduce substitution effects and to provide incentives to increase contracts' length.
Finally, the main reasons for wood substitution are analysed and measures to reduce substitution are recommended.
Reconstructing trees with amino acid rather than nucleotide sequences was also proposed: Analyses of amino acid sequences can avoid the effect from biases of codon usage (Inagaki et al. 2004) and reduce substitution saturation (Mathews et al. 2010).
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Inversion of CE1 may contribute to its acquisition of purifying selection, causing a slightly reduced substitution rate.
Under the hypothesis of reduced substitution rates in the sperm whale, the expectation was slow rates in the sperm whale relative to other cetaceans.
In the IRs of cycad plastomes, the reduced substitution rates and GC-biased mutations are associated with a GC-biased gene conversion (gBGC) mechanism.
As a result, in the IR regions of cycads, GC-biased mutations together with reduced substitution rates can best be explained by gBGC.
The significantly reduced substitution rate in the mouse and human lincRNA exons was reproduced when all lincRNAs (intron containing and intronless) were used for the calculation of exon substitution rates (supplementary tables S2 and S3, Supplementary Material online).
Evolutionary rate comparisons (supplementary table S2, Supplementary Material online) demonstrated a significantly reduced substitution rate for human lineage when compared with rodents, a process known as "hominid slowdown" or "fast rats," respectively.
In general, lncRNAs show reduced substitution and insertion/deletion rates compared with random expectation, which has been interpreted as a signature of purifying selection (Ponjavic et al. 2007; Guttman et al. 2009).
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