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Unfortunately, these drugs cross the placenta and affect the circulation of the fetal kidneys, and, more importantly, reduce stimulation of AT II receptors.
These falls in [Ca2+]o will reduce stimulation of CaSR and thereby increase NSCC activity in the vast majority of neocortical nerve terminals [28].
Finally, we found that p31(comet) mutations that disrupt either MAD2 or TRIP13 binding also significantly reduce stimulation of TRIP13 by p31(comet) + MAD2.
Second, the later occurring action of furosemide (due to the induced sodium and water depletion) is to reduce stimulation of the afferent arteriolar stretch receptors and carotid / aortic sinus baroreceptors, thus stimulating renin release [ 12, 17].
Another approach is to add atropine (10-6 mol·l-1) and indomethacin (10-6 mol·l-1) thethe isolation solution in order to reduce stimulation of mucus production during the isolation procedure.
A reduced EMG indicates reduced motor nerve activity, which would lower the level of "residual" interstitial acetylcholine and reduce stimulation of α2 Na,K-ATPase by interaction with the nAChRs.
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We hypothesized, that activation of the cardiac adenosine-A1 receptor by capadenoson would reduce stimulation-induced NE release and consequently blunt the heart rate response during physical stress particularly in SHR.
The researchers hypothesized that these free-floating copies of the receptor would serve as decoys, capturing fibroblast growth factor molecules and reducing stimulation of the cartilage cells' receptors.
The observed changes in growth and proliferation may arise because of either the reduced stimulation or the lack of dynamic stimulation or a combination of both.
Currently, we can only speculate about possible causes but, our data imply that FMS patients were able to tolerate single painful stimuli well while repeated stimulation (i.e. during the experiment) were less tolerated resulting in reduced stimulation intensities.
Other possible effective strategies include improved parental responsiveness, reduced stimulation and the use of sucrose.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com