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The importance of this sensitizing mechanism is underscored by the ability of prostaglandin synthesis inhibitors to reduce sensitization.
Research leading to mechanistic descriptions of migraine-related acute CA and interictal WPH may lead to treatments that more effectively reduce sensitization and its clinical consequences.
Changes in trunk neuromuscular control following HVLA spinal manipulation may reduce sensitization or muscle fatigue effects related to repetitive movement.
Furthermore, a recent study from South Africa indicated that Ascaris may have dual effects, being able to both enhance EIB development and reduce sensitization to inhalant allergens [ 29].
The present results indicate that changes in trunk neuromuscular control following HVLA spinal manipulation may reduce sensitization or muscle fatigue effects related to repetitive movement.
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However, GASP-1 KO mice exhibited significantly reduced sensitization that also developed more slowly compared to WT mice.
However, given the multitude of inhibitory effects of Bay 11-7082, is is difficult to ascertain whether the increased or reduced sensitization to PDT is the result of NF-κB inhibition or of impaired AP-1 activity.
"Reduced exposure of infants to allergenic foods appeared to reduce food sensitization and allergy primarily during the first year of life," Zeiger wrote.
This mechanism may reduce central sensitization phenomena and spinal NP.
The endogenous opioid peptide endomorphin-1 was found to reduce peripheral sensitization in acutely inflamed rat knees [ 10], as well as ameliorating joint inflammation [ 11].
For example, mutations in the circadian genes period (per), clock (Clk), cycle (cyc), and doubletime/ discs overgrown (dco) reduce behavioral sensitization to cocaine (Andretic et al. 1999).
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CEO of Professional Science Editing for Scientists @ prosciediting.com