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The modified receiver operating characteristic curve in Figure 2 shows that variation of the threshold for weighted trends may reduce sensitivity for better specificity (less FP alarms per patient-year of monitoring).
This mode of action is shared by the SPs, and mutations that cause target-site insensitivity for DDT often also reduce sensitivity for the SPs (Brengues et al. 2003).
The specificity of an assay that depended on the intersection of the specificity of the antibody and the FRET peptide would not work for MMP-12, given that any cross reactivity of the antibody with other MMPs, in particular MMP-8 and MMP-9, would saturate the capture antibody binding sites on the plate and reduce sensitivity for MMP-12.
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This variability reduces sensitivity for detection of effects in clinical studies.
Standard LGE imaging is possible after the bolus, although the sensitivity of LGE may decline since doses as low as 0.1 mmol/kg have reduced sensitivity for myocardial infarction.
Our results suggest a reduced sensitivity for the emotional qualities of speech and music in alexithymia during affective categorization.
An additional possibility is that females exposed to defeat may have developed reduced sensitivity for detecting social stimuli.
Like other SBE platforms, it is hampered by many of the same limitations - difficulties with long repeats, reduced sensitivity for neighboring mutations, and reliance on a known reference sequence relatively similar to the genome to be assayed.
Compared to zebrafish, we found a substantially reduced sensitivity for chemicals like lithium chloride for medaka.
Both tests have reduced sensitivity for smear-negative samples, and conventional DST is needed for expanded drug resistance testing.
77, 78 R2 alone, without coinheritance of factor V Leiden, neither reduces sensitivity for APC nor increases venous thrombosis risk.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com