Sentence examples for reduce polymerase from inspiring English sources

This is also consistent with the observations that although PKA hyper-activation blocked SCH9 deletion to reduce Polymerase III-dependent transcription of tRNA genes, overexpressing MAF1 in such condition did not reverse the blockage.

It is already known that many of the cancer-associated variants of pol β that produce structural perturbations much less profound than those produced by the L22P mutation can significantly reduce polymerase fidelity.

By contrast, all vRNPs with the avian PB2-mammalian PB1 pair had reduced polymerase activities (lanes 5 8).

In addition, PB1-F2 binding to PB1 affects the intracellular localization of the polymerase protein and reduces polymerase activity, potentially affecting virulence [ 260].

Spreading of DNA methylation could be related to weakening of transcription initiation from P35S and reduced polymerase occupancy of the coding region.

These mutator effects suggested a defect in replication fidelity at a step preceding mismatch repair (for example, reduced polymerase base selectivity and/or proofreading) [ 7].

Earlier work had shown loss of Arg-283 hydrogen bonding and van der Waals interactions with the minor groove of the templating nucleotide of the nascent base pair decreases catalysis and reduces polymerase fidelity [ 14- 16].

Application of ultrafiltration with Millipore filters (YM100) was reported to reduce Taq polymerase sensitivity in one case [12], but not in another [13].

In contrast, flavopiridol, a potent CDK9 inhibitor, did reduce RNA polymerase II phosphorylation and increased p53 levels.

These compounds did not induce p53 accumulation or reduce RNA polymerase II phosphorylation at the concentrations tested, indicating that growth inhibition was not due to inhibition of transcriptional CDKs but was a result of direct inhibition of only CDK2 and CDK1.

Bean et al. demonstrated that LNA and ENA (2′- O, 4′-C-ethylene-bridged nucleic acids) oligomers were able to reduce RNA polymerase and SP1 transcription factor occupancy in the promoter of both the progesterone and androgen receptor genes, and LNA-based AGOs were recently reviewed.