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These indications that BMP levels are increased under pathological conditions are consistent with our findings that a treatment to reduce pathology leads to a reduction in astroglial BMP levels.
Bard, F. et al. Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease.
We found that lowering levels of ataxin 2 in mouse, either by knockout or with antisense oligonucleotides (ASOs) can markedly extend survival and reduce pathology in TDP-43 transgenic mice (Becker et al., Nature 2017).
Decreasing susceptibility (e.g. by pharmaceutical approaches) may be enough to significantly reduce pathology.
In addition, acute immune activation has been previously shown to reduce pathology in AD murine models (DiCarlo et al., 2001; Herber et al., 2007).
However, regulatory pathways that either develop intrinsically to reduce pathology, or result from parasite immune evasion strategies, can block successful immunity and render the host susceptible.
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Importantly, 5% ribitol treatment significantly reduced pathology of the diaphragm.
Baruch, K. et al. PD-1 immune checkpoint blockade reduces pathology and improves memory in mouse models of Alzheimer's disease.
This data indicates that attenuation of the pulmonary neutrophil response in aspiration pneumonia reduces pathology very significantly but does not reduce the efficiency of pulmonary bacterial clearance.
Therapeutic reduction of ataxin-2 extends lifespan and reduces pathology in TDP-43 mice NATURE Becker, L. A., Huang, B., Bieri, G., Ma, R., Knowles, D. A., Jafar-Nejad, P., Messing, J., Kim, H. J., Soriano, A., Auburger, G., Pulst, S. M., Taylor, J. P., Rigo, F., Gitler, A. D. 2017; 544 (7650): 367-?
CONCLUSIONS: Treatment with apoE mimetics significantly improved behavior, reduced inflammation and reduced pathology in CVND-AD mice.
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