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Our therapy aims to reduce oxygen consumption and improve oxygen delivery.
Recent studies show that inorganic nitrate, an inorganic anion abundant in vegetables, can reduce oxygen consumption during physical exercise and attenuate oxidative stress in animal models of disease.
In nearly all these cases, the adaptation to hypoxia involves systemic and cellular responses aimed to reduce oxygen consumption and optimize its utilization.
Avicins have also been shown to reduce oxygen consumption and levels of cellular ATP [13], [14], which can lead to a hypo metabolic state [12] [14].
But in parallel, and with a decay constant similar to the one in the equation explaining the decrease of buoyancy with depth, they decreased foot-stroke frequency exponentially, a behaviour that enables birds to reduce oxygen consumption.
They prevent arrhythmias, lower heart rate and reduce oxygen consumption without detriment to work output.
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Consideration of kidney function is important for evaluating REE because the oxygen consumption of the kidneys is high – estimated to be between 5.6% and 20% of the total metabolic rate [ 28, 29] – and failing kidneys may have reduced oxygen consumption contributing to reduced REE [ 29, 30].
Constriction of preglomerular vessels, although possibly contributing to the CM-induced drop in GFR, has small if any impact on medullary oxygenation: blood flow reduction in medullary vessels that emerge from efferent arterioles is usually accompanied by reduced solute reabsorption and, thus, reduced oxygen consumption.
Reduced oxygen consumption was previously postulated as a mechanism for improved oxygenation in a severe ARDS patient with an arterial partial pressure of oxygen to inspired oxygen (P F) ratio of 58 and elevated respiratory rate [10].
Reduced oxygen consumption was previously postulated as a mechanism for improved oxygenation in a severe ARDS patient with an arterial partial pressure of oxygen to inspired oxygen (P F) ratio of 58 and elevated respiratory rate [ 10].
Reduced oxygen consumption is an immediate effect, however, whereas the improvements in oxygenation elsewhere reported were seen after 24 hours [7, 8, 15].
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