Sentence examples for reduce origin from inspiring English sources

Reduced availability of the MCM complex thus could reduce origin firing during S phase and slow down fork movement, both of which has been observed in aged HSCs and was caused by knock down of MCM4 or 6 in young HSCs (Flach et al., 2014).

It provides the capability to reduce origin server load and bandwidth requirement, reduce network bandwidth usage, and reduce client-side latency that leads to improved scalability and performance with lower cost.

For any mutation that reduces the origin bias, it would be important to alter both ARSs in the plasmid identically to distinguish between mutations that reduce origin function from those that are specific to the origin's ability to respond to the bias determinant.

The MGS mutation in the C-terminal domain of Orc6 impedes binding of Orc6 to the Orc3 insertion and recruitment of Orc6 into metazoan ORC, likely resulting in reduced origin licensing.

These mutations did substantially reduce the origin bias.

Since PREP1 down-regulation induces a decrease in the inter-origin distance (Fig. 2C,D), and considering constant processivity of DNA polymerases in siPREP1 and siLuc cells, altogether our data strongly suggest an increase in simultaneously activated origins within LRRs and/or TTRs, which normally show reduced replication origin activity23.

Metabolic acidosis reduces the release of leptin from adipocytes and uremic factors of unclear origin reduce leptin gene expression in adipocytes probably as a negative feedback due to decreased elimination [ 74, 75].

In rodent early cortical development, all the Layer V neurons of the neocortex project to the spinal cord but subsequently selective axon pruning reduces the origins of the CST to the sensorimotor cortex (Oudega et al. 1994).

"By doing that we managed to contain the area to the place of origin and reduce significant damage to the whole campsite," he said.

The annual participation of Moldova at the Global Forum on Migration and Development and the regular interactions between local actors, international organizations and European experts have facilitated the internalization among the policy-makers of the belief that greater development in the migrants' countries of origin will reduce emigration and of the migrants' central role in this dynamic.

Analyses were adjusted by province of origin to reduce this effect, but this disproportion should be considered during interpretation.