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These are not only safer but may reduce migraine frequency and intensity as well [25 32].
Several drugs have been shown to reduce migraine symptoms, or elicits migraine-like attacks [3].
Clopidogrel, given as an aspirin alternative, might also reduce migraine frequency [17, 18].
Physical activity may be a potential migraine treatment strategy to reduce migraine frequency, pain intensity and duration [6].
Unfortunately, preventive treatment is often insufficient to substantially reduce migraine frequency or it is not well tolerated.
Different studies demonstrated that topiramate at a dose of 100 mg/day, can reduce migraine days in CM patients when compared with placebo.
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They noted that for people who want to reduce migraines without the side effects of drugs, exercise may be a good alternative.
Migraine prevention not only reduces the frequency, severity, and duration of attacks, but was shown to reduce migraine-related socio-economic burden [9].
Wider access to these treatments as result of their reclassification (termed rescheduling in Australia) may result in improved treatment of migraine and reduce migraine-related disability [6], thus helping to address this public health priority [4].
In summary, more attention should be paid to metabolic implications of migraine and its treatment to further improve, or at least not worsen, patients' conditions and reduce migraine-related comorbidities and complications.
The best way to sort out all these questions would be to conduct a large, randomized and controlled trial among migraine sufferers to see if specific vitamin supplementations can prevent or reduce migraines, Hagler concluded.
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