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The activity of some CA isozymes has been reported to decline in certain parts of the human brain with age [84] and silencing of the CA gene, cah-3, in the nematode Caenorhabditis elegans is reported to reduce lifespan [85].
The genetic interaction between cep-1 and smg-1 is specific, as cep-1 RNAi alone did not reduce lifespan (Table 1; Figure 5).
LEDs provide a cheap and reliable light source with a long lifespan (>50 000 hours), repeated on-and-off switching does not reduce lifespan, and no darkroom is required for their operation.
Although severe hyperoxic environments were known to reduce lifespan in flies, the embryos from SO2A flies were able to complete development to adult stage and reproduced indefinitely in 90% O2.
Here, nutritional insufficiency leading to deficits in weight and/or growth (particularly during the key developmental periods of gestation and lactation) when coupled with postnatal nutritional excess increase the risk of adult metabolic disease [43] [45] and actually reduce lifespan in male mice [7].
We examined whether policies to increase life expectancy were compatible with those to reduce lifespan variation.
Similar(36)
Living under the perpetual and pervasive threat of racism seems, for black men and black women, to quite literally reduce lifespans.
While their results suggest that sexual dimorphism of IGF-1R lifespan regulation is conserved between 129/SvPas and C57BL/6J genetic background, they also point to possible genetic modifiers that reduce lifespan-extending effects of IGF-1R inactivation in C57BL/6J mice.
Although we did not include a chow fed control group, we assume that feeding of our semisynthetic diets did not lead to a reduced lifespan.
The end result is a considerably reduced lifespan that is marred by reduced levels of independence, with few novel treatment options available.
In both cases restriction of thermoregulation reduced lifespan.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com