Exact(7)
Rearing these mutant animals at reduced temperatures decreased intracellular accumulation, increased secretion and was sufficient to reduce lethality for some mutations (21).
The number of bullets in an assault weapon -- the magazine size -- could also be reduced to reduce lethality.
Other investigators also showed that the intranasal challenge with a sub-lethal dose of the bacteria has shown that MAbs against PS, LPS, and glycoproteins of BP and/or BM significantly reduce lethality of infections in mice.
In C. albicans, however, these mutations also reduce lethality in Toll-deficient Drosophila (Ben-Ami et al., 2011).
The dose of morpholino for each gene was initially titrated to reduce lethality at early stages of development (not shown).
Morpholino injection trials with greater than 25% lethality at 24 hpf were discarded, and the morpholino dose was adjusted to reduce lethality.
Similar(53)
As shown in Fig. 5a, the Mecp2 Δ3–4/Y mice presented significantly reduced lethality compared to Mecp2-null animals.
In vivo, the RMAE markedly reduced lethality, hemorrhage, edema, muscle and liver toxicities induced by Cc venom.
We predict that reduced lethality through poor SIT methods or imperfectly efficacious vaccines will impact efforts to control disease spread.
Furthermore, the intraperitoneally injected OMVs (25 µg) caused delayed and reduced lethality in CD14−/− mice than in wild-type mice (Fig. 6C).
Optimizing the dosage of CDDO-Im and/or the administration schedule might help in reducing lethality while preserving the efficacy of the drug against CLL/SBL.
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