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Now, this belief has gotten a dose of scientific support from a study that suggests that the central nervous system can regulate pain and even reduce joint damage in arthritic rats.
There is no research in PsA addressing the concept of tight control of inflammation to reduce joint damage.
Disease-modifying antirheumatic drugs (DMARDs) slow the natural course of the disease, reduce joint damage and pain, and retard loss of function and disability [ 5- 8].
Glucosamine is a known potent antioxidant and has been used in osteoarthritis because of its ability to reduce joint damage [ 23].
Treatment aims to control pain and inflammation and to reduce joint damage, disability, and loss of function, thereby improving quality of life.
In addition, MTX may have the potential to reduce joint damage in chronic CPPD arthropathy, given its pharmacological properties and established protective effects in RA [ 5], and this might be considered as an outcome in future studies.
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Furthermore, PDUS scores reflect changes in disease activity in patients treated with TNFα antagonists, and patients with reduced PDUS scores following therapy have reduced joint damage progression [19], [20].
Our observation reflects only indirect evidence of reduced joint damage in rheumatoid arthritis.
Prophylaxis with factor VIII (FVIII) reduces joint damage if initiated early.
These findings suggest that the combination of TNFα-blocking therapy with methotrexate not only reduces joint damage but also vascular "damage" in patients with RA.
Other register data also indicated that starting DMARD treatment early and at lower disease activity levels also results in improved remission rates and reduced joint damage [ 23– 27].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com