Sentence examples for reduce its interaction from inspiring English sources

In this light it is notable that the Y660F mutation of Themis2 also appears to reduce its interaction with Grb2, although not to the extent of the 2PA proline mutant (Fig. 3b).

However, NBR1 phosphorylation might slightly reduce its interaction with SQSTM1 as shown in GST affinity isolation and coimmunoprecipitation experiments.

This charge reversal may significantly reduce its interaction with Torpedo nAChR as mutation of K49 to E49 in α-cobratoxin cause 53 fold decrease in binding affinity [ 18].

At the post-translational modification level Beclin 1 can be phosphorylated by DAP (death-associated protein) kinase within its BH3 domain in order to reduce its interaction with Bcl-2 [ 17].

To examine whether the redistribution of importin α to the membrane fraction was sufficient to reduce its interaction with kif2a in the cytoplasm, we measured the amount of importin α capable of interacting with recombinant kif2a added to cytoplasmic extracts at stage 3 and stage 8 in quantitative pull-down experiments.

Finally, compound IV with all three 3,4,5 substituted sites reduces its interaction scheme to stacking contacts, and the columns thus formed are essentially non interacting.

In contrast, the Ala248Val mutation enhanced agonist-induced arrestin-3 binding to the β2-adrenergic and D2 dopamine receptors, while reducing its interaction with the D1 dopamine receptor.

Phosphorylation of Npl3 reduces its interaction with RNAP II and RNA.

CKIδ's phosphorylation of XDpr1a reduces its interaction with XDsh and transforms XDpr1a from a promoter to an inhibitor of β-catenin degradation.

To further show the importance of XDsh in the phosphorylation of XDprIa by CKIδ, we examined whether a mutation in XDsh that reduces its interaction with XDpr1a's PDZ-B domain still promotes the phosphorylation of XDpr1a by CKIδ.

GATA4 is methylated by EZH2 which reduces its interaction with its coactivator p300 [ 76].