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Drugs that block MMP activity, or are free radical scavengers, significantly reduce ischemic damage.
CINODs may also reduce ischemic damage to compromised myocardial tissue.
We report a technique of selective cerebral and myocardial perfusion with the aim to reduce ischemic damage to brain and heart.
For example, DHA and EPA can ultimately increase arrhythmic thresholds, increase the threshold of ventricular fibrillation, increase heart rate variability, reduce ischemic damage, and favorably affect autonomic tone [ 30- 32].
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Modeling the caspase cascade would suggest molecular locations where one might alter the necrosis/apoptosis balance and reducing ischemic damage [33].
Intracerebral administration of the CDK inhibitor flavopiridol significantly reduced ischemic damage during focal and global stroke [39], [40].
Recent studies have shown that the intracerebral injection of MSCs transfected with the BDNF or GDNF gene resulted in improved function and reduced ischemic damage in a rat stroke model of middle cerebral artery occlusion [83].
Several studies suggested that VEGF reduces ischemic damage via ERK-1/2 dependent pathways [ 11, 13].
Chungsimyeonja-eum (CSYJE) is an herbal prescription used in traditional Oriental medicine for treating cerebral infarction by reducing ischemic damage.
Furthermore, systemic injection of SOD was used previously to prevent ROS production following global forebrain ischemia [ 53], a protocol which efficiently reduced ischemic damage.
Importantly, the equation predicts that both the restoration of MBF, and of capillary flow patterns, represent key aspects of reducing ischemic damage and reperfusion injury after myocardial ischemia.
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