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With a rat Achilles tendon injury model, exogenous SDF-1 alpha was shown to reduce infiltration of inflammatory cells and enhance migration of fibroblast-like cells into the scaffold at 4 days and 1 week post-surgery.
For example, deletion of a single allele of NF kB (RelA/p65 subunit) was sufficient to considerably reduce infiltration of macrophages, fiber necrosis and calcification in dystrophic muscle in mdx mice (DMD mouse model).
Lipoxins, resolvins and protectins reduce infiltration of leukocytes, suppress inflammation, show neuroprotective properties, inhibit oxidative stress-induced apoptosis of cells, inhibit proinflammatory cyclooxygenase-2 expression and tumor necrosis factor alpha (TNFα) production, enhance wound healing and promote brain cell survival by enhancing neuroprotective gene-expression programs [ 9- 11].
Air conditioning and its coincidence with closing of windows, and the winter season (when windows are also generally closed) all function to reduce infiltration of ozone and PM by reducing air exchange (Allen et al. 2003; Liu et al. 1995; Wallace and Williams 2005).
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Urbanisation increases the imperviousness and reduces infiltration of precipitation (El Alfy 2016).
IFN-β delivery strongly reduced infiltration of mononuclear cells possibly by inhibiting cell adhesion molecules.
The use of a monoclonal CD11b antibody both enhances tumor response to radiation and reduces infiltration of myeloid cells [50].
Continuous ploughing of land may result in poor soil aggregate and soil crusting that reduces infiltration of rainfall.
IL-10 gene modified iDC-treated EAM rats showed improved cardiac function and reduced infiltration of inflammatory cell into myocardium.
Consequently, through G-CSF blockade, we found that anti-G-CSF treatment suppressed the tumor growth as well as reduced infiltration of MDSCs in the colon.
In addition, anti-G-CSF treatment suppressed the tumor growth as well as reduced infiltration of MDSCs in the AOM/DSS mouse model of CRC.
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