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However, aggregation cannot be the main cause of mortality, as interventions that reduce foci may not alter lifespan (Cohen et al., 2010; van Ham et al., 2010).
To assess whether some VLT hits could reduce foci numbers, we performed a quantification of the number of foci in Drosophila by using fluorescence in situ hybridization (FISH).
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A non-consequential Leu157 to Ala (L157A) mutation that displayed much reduced foci formation and TfR binding had normal TfR distribution, normal surface TfR level and normal Tf internalization.
From this library gemcitabine (a nucleoside analogue) and chromomycin A3 (a glycosidic antibiotic) reduced foci in both DM1 and DM2 cells.
Ro 31-8220 and chromomycin A3 reduced foci numbers at concentrations that did not have a fully matching toxic effect although the viability of the cells was reduced relative to controls (Fig. 2A D).
When heart rate activity was high, infants may have reduced focus on the tasks, corresponding with reduced cognitive load.
By reducing focus on one of the platforms, you start losing a whole market segment – and additional revenue source.
Under stress, attention appears to channel or tunnel, reducing focus on peripheral information and centralizing focus on main tasks [32].
Compact liquid geometry provides additional benefits in reducing focus-magnet stand off distance for heavy ion drivers and improving target performance.
In healthy folks, poor sleep is widely attributed to impaired memory, reduced focus, and poor emotion regulation.
Thus, we interpret our findings to indicate that compared to placebo MP reduced (focused) the use of attentional resources in the human brain that are necessary to achieve similar levels of performance on a task.
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