Upon treatment of cancer cells, this should reduce expression of CBP-regulated transcription, leading to reduced tumorigenicity and enhanced differentiation.
For example, Usf1 knockout might reduce expression of a synchronizing signal in the SCN leading to reduced amplitude of the behavioral rhythms.
Roscovitine can interrupt activation of NF-κB and reduce expression of TNF-α-induced proinflammatory gene, thus inhibiting intimal hyperplasia.
Statins have been reported to reduce expression of matrix metalloproteinases (MMPs), catabolic enzymes centrally implicated in the pathophysiology of osteoarthritis [3, 4, 5].
However, XA21-LRR1Ri line 13-6-1 does not reduce expression of LRR1 and did not have reduction in Xa21 transcripts (Fig. 3).
Our rationale was that compounds that reduce expression of the mutant protein would be beneficial to slow onset and/or disease progression.
This is thought to be mediated through its ability to promote keratinocytes proliferation [67], enhance revascularization [68], reduce expression of tumor necrosis factor-α (TNF-α) and attenuate macrophage infiltration [69].
Among already available agents are the HMG-CoA reductase inhibitors that reduce expression of P-selectin so as to reduce anchoring of EVs to the venous endothelium [76 81, 145].
In particular, disorders where it is beneficial to overexpress or reduce expression of a transgene in a particular anatomical region to the exclusion of global delivery are especially attractive targets.
As an approach to understanding the role of the α1 subunit of the GABAA receptor, ribozymes were designed to reduce expression of this subunit protein by hydrolysis of α1 subunit message and antisense inactivation.
Preliminary research has shown that preoperative metformin administration can reduce expression of tumor markers.
