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While the dissemination of the recommendations alone will not effectively reduce dissemination bias, their full or even partial implementation should help reduce dissemination bias.
Confidence in effectiveness whether the group was confident that if this recommendation were implemented it would effectively reduce dissemination bias.
22 Once more registries adopt this approach and once platforms allowing metasearching are available, clinical trial registers will become essential tools to reduce dissemination bias.
Together, these results show that SFV-IL-12 induce a marked local antiangiogenic effect in implanted 4T1 tumors, which may contribute to inhibit primary tumor growth for a limited period of time, as well as to reduce dissemination of metastasis in the organism, prolonging consequently animal survival.
The following five explicit criteria, which are conceptually based on the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach for developing recommendations, 19 20 were assessed for each recommendation: Confidence in effectiveness whether the group was confident that if this recommendation were implemented it would effectively reduce dissemination bias.
Based on the data gathered in each OPEN work package (ie, conducted surveys, qualitative studies, and systematic reviews; see online supplementary figure), each of these groups formulated 4 7 recommendations on how to reduce dissemination bias tailored to their respective key group in the knowledge translation process.
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Comprehensive set of evidence-informed recommendations aimed at reducing dissemination bias based on work conducted as part of European Union FP7 project (Overcome failure to Publish nEgative fiNdings (OPEN) project; http://www.open-project.eu).eu
Intriguingly, Vardenafil may not only overcome one particular challenge to brain tumour chemotherapy since it crosses the blood brain barrier, but its inhibition of ABCB1 may also have a collateral benefit in reducing dissemination and invasion of drug resistant tumour cells [ 44].
Nonspecific character of AOPs gives rise to assume that the TiO2/UV process could efficiently reduce the dissemination of many viruses, e.g., measles, mumps, rubella, or smallpox.
Some authors, like Han et al. [54], believe the TiO2/UV process can be an efficient tool to reduce the dissemination of the SARS virus, a helical enveloped virus from the ssRNA group.
Viral titers in tail are similar between antibody treated and non-treated animals (Figure 4C), but the former had lower virus titer in ovaries compared to non-treated animals (Figure 4D), indicating that the antibody response seems to be efficient in reduce viral dissemination to internal organs.
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