Alginate freely diffused into mucus and reduced diffusion of 500 nm beads.
After drug loading, α-galactosidase treatment generates additional physical crosslinks in the hydrogel matrix as well as between the drug oligomer conjugate and the hydrogel, which reduces diffusion of the drug oligomer conjugate significantly.
In the smooth surface model, reduced diffusion of buffered Ca2+ would have little effect on the peak Ca2+ concentration (Fig. 4a).
Likewise, the biofilm can act as a barrier which reduces diffusion of the anolyte towards the electrode, all the while behaving like a porous material.
The biofilm can act as a barrier which reduces diffusion of the anolyte towards the electrode, all the while behaving like a porous material.
Reduced diffusion of water has been attributed to the increased cellularity of malignant lesion, with reduction of the extracellular space and restriction of the motion of extracellular water [ 7, 8].
It is likely that this inhibition also applies to reduced diffusion of proteoglycans and gelatinases MMP2 and MMP9 or other degrading enzymes out of the cartilage or from their origin to the targets within the cartilage.
The drag between solid and solute phases is more subtle and a law must be chosen to model effects related to reduced diffusion of large solutes passing through a soft solid phase as observed in brain tissue (Nicholson 2001).
Similar to endocytic BAR and F-BAR domains, the BAR domain of Pinkbar and PI 4,5 P2 displayed very slow recovery on planar membranes, suggesting that severely reduced diffusion of phosphoinositides associated with the BAR domain scaffolds is not dependent on membrane curvature.
