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Pirfenidone is InterMune 's investigational drug candidate for the treatment of patients with idiopathic pulmonary fibrosis to reduce decline in lung function.
Compared with placebo, pirfenidone treatment was shown to reduce forced vital capacity (FVC) decline, reduce decline in 6-min walk test distance and increase progression-free survival.
The goals of care of different CAPs vary and contain the possibility to solve problems, to reduce decline or to create an atmosphere of improvement [ 13, 14].
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Marine protected areas (MPA) are one management tool that can potentially reduce declining shark populations.
With shares at recent highs and the company still working to reduce declining margins in case interest rates rise, investors and analysts are confused about where Dimon plans to take Bank One.
Although DHA had no impact on cognitive or functional decline based on intent to treat AD, in non-ApoE4 carriers, DHA supplementation appeared to reduce declines in MMSE and Alzheimer Disease Assessment Scale-Cognitive (ADAS-Cog).
Physical exercise that targets modifiable risk factors and neuroprotective mechanisms may reduce declines in cognitive performance attributed to the normal aging process and protect against changes related to neurodegenerative diseases such as Alzheimer's disease and other types of dementia.
The investigators reported that combination therapy with donepezil and memantine had a greater influence on cognitive improvement, reduced decline in activities of daily living, and a reduced frequency of new behavioral symptoms versus the donepezil monotherapy group.
The INPULSIS trials only identified that a dose of 150 mg twice daily reduces decline in lung function [7].
Comparing the development of vision measures against the natural loss expected to occur over the course of 48 weeks, most measures showed reduced decline, and these reductions were significant for normal illumination VA and CS.
A trend towards reduced decline, narrowly missing significance, was also observed on the praxis higher-order subscale of the SIB in rivastigmine-treated patients compared with placebo (rivastigmine, -0.33 (0.45); placebo, -1.43 (0.46); P = 0.051).
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