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ERAs prevented the contractile response to low ET-1 concentration, but failed either to reduce contraction when ET-1 levels were high or to relax uterine arteries pre-contracted with ET-1, even when they were combined.
Alternatively, nRHO-1(G14V) expression in pharyngeal motor neurons may alter more than ACh release, for example neuropeptides and octopamine that can both reduce contraction of the pharyngeal muscle [49].
Although we acknowledge that compound C did itself reduce contraction to U46619, in the presence of compound C, simvastatin had no additional effect on arterial contractility.
Another KCNQ 2/3 activator meclofenamic acid (MFA) was tested (Peretz et al., 2005) and found to significantly reduce contraction amplitude, AUC and baseline tone (n = 5, P < 0.05; Figure 2B E), without affecting frequency (P > 0.05).
For example, AS variants of the troponin I gene reduce contraction efficiency, and AS-generated titin isoforms alter cardiac stiffness in individuals with dilated cardiomyopathy (Makarenko et al., 2004; Feng and Jin, 2010).
They found that the subjects adapted their gait to reduce contraction of quadriceps and that they tended to walk with symmetrical gait which meant that the contralateral leg was almost equally affected.
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What is more, the same study showed that 4-OH-TCB could reduce contractions of rat myometrial strips, suggesting that the relaxing effect of 4-OH-TCB is mediated through blockage of GJIC.
Microtubule proliferation reduces contraction by impeding sarcomeric motion; modulation of sarcoplasmic reticulum Ca2+ release may also be involved in this effect.
Also, the addition of bioactive glass has reduced contraction of the PLGA/collagen scaffold in contact with the culture medium (data not shown).
The engineered tissues containing cells transfected to overexpress one of the has isozymes had significantly increased retention of hyaluronan within the scaffold; elevated hyaluronan secretion into the culture medium (all but has-2); reduced contraction; reduced collagen density; and significantly altered material properties compared to the LXSN controls.
Reduced contraction strength in three failing hearts was confirmed by tagged MRI and tissue was obtained directly from the operating theatre (e.g. Figure 1).
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