Sentence examples for reduce complement from inspiring English sources

In an in vitro model of extra corporal circulation, compstatin was found to reduce complement and granulocyte activation.

In this example, the C region has been mutated to reduce complement activation (see below).

For example, the CTLA4-Ig Fc is mutated to reduce complement activation, which may reduce the incidence of infusion reactions.

Recently, some studies have shown that WNV NS1, but not JEV, could bind to CFH, and thereby reduce complement activation on the virus in vitro 15– 15.

In conclusion, the present work demonstrates that low concentrations of citrate can reduce complement and granulocyte activation in human whole blood in vitro.

Citrate has been proven to reduce complement activation in human blood and several studies have reported beneficial effects when replacing acetate- with citrate-containing dialysis fluid [ 13, 24, 35– 35].

To improve the side-effect profile associated with ch14.18, a humanized anti-GD2 mAb was developed with a single point mutation (K322A) to reduce complement-dependent lysis [91].

Inter-alpha-inhibitor H4 and H3, for example, have been shown to reduce complement-dependent lung injury in vivo [ 19], suggesting that their decrease could be a contributing factor to the hemorrhagic state.

In vivo studies have demonstrated that statins reduce complement-dependent leukocyte migration [ 37] and that they may be protective against ischemia-reperfusion injury [ 38], in which complement activation plays an important role.

The results demonstrated that RJ may attenuate LPS-induced ALI via reducing the production of pro-inflammatory mediators, and reducing complement deposition and radicals.

The EDL complexes also showed increased resistance to DNase digestion in the presence of negatively charged lipid, while reducing complement activation in serum.