Sentence examples for reduce clearance from inspiring English sources

Biodegradable polymeric nanoparticles are widely recognized as efficacious drug delivery vehicles, yet the rational engineering of nanoparticle surfaces in order to improve biodistribution, reduce clearance, and/or improve targeting remains a significant challenge.

Therefore, downregulation of Sesn1, Sesn2, Ampkb1 in AR100 motor neurons may result in a loss of p53-dependent inhibition of mTOR, mediating increased energy usage which, in turn, may not only intensify the mitochondrial deficits but may also reduce clearance of damaged mitochondria, causing increased cell stress.

Kp-10 was found to significantly reduce clearance, in keeping with decreased blood flow and providing further evidence for vasoconstrictor activity.

Thus, expression of both VLDLR's and LRP1 would not only be expected to increase the quantities of LDL and VLDL, but would also reduce clearance rates of very low density lipoproteins into denser particles in both treatment-naïve and anti-retroviral treated individuals [97] [99].

21, 24 Metformin is not metabolized prior to its complete excretion in the urine, thus decreases in renal function will reduce clearance of the medication.

An interesting approach to reduce clearance and to achieve targeted delivery involves the surface modification of nanoparticles to contain ligands which bind to specific cell types.

Reduced clearance allows the use of lighter-grade oil.

The new setup is aimed at reducing clearance leakages and at improving the dynamic response of the needle to the electrical command.

However, whether the excess lipemia is associated with an impaired suppression of VLDL-TG secretion and/or reduced clearance into adipose tissue is unknown.

It notes that as public confidence grows, the crime reporting rate increases, which reduces clearance rates in the absence of more police resources.

Previous studies in our laboratory using a model of resting ischemia without reperfusion and without injury demonstrated significantly reduced clearance in ischemic zones resulting exclusively from reduced flow [32].