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DFIMA algorithm uses matrix-based pruning technique to reduce candidate size.
InChIKey filtering has now been added to reduce candidate redundancy due to stereoisomerism, as stereoisomers inflate candidate numbers but cannot (usually) be distinguished with MS/MS.
At the same time, there is increasing pressure on the pharmaceutical industry to improve its productivity and reduce candidate drug attrition.
New features include the retrieval of reference, data source and patent information via ChemSpider and PubChem web services, as well as InChIKey filtering to reduce candidate redundancy due to stereoisomerism.
Uploaded VCF (variant call format) files are passed through custom user filters in order to substantially reduce candidate search space by removing likely benign variation.
Another strategy to reduce candidate elemental compositions is through filtering using a set of heuristic rules developed by Kind and Fiehn.
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Alternatively, the reduced candidate mechanism (RCM) approach [12], a piece of our prior work, has been presented.
The process consists of iterative analysis in order to identify and transform the classes responsible for the structural complexity and effectively reducing candidate components' sizes.
In a bid to enhance the search performance, this paper presents an improved version of reduced candidate mechanism (RCM), an algebraic codebook search conducted on an algebraic code-excited linear prediction (ACELP) speech coder.
We next used smaller overlapping deletions to further delineate a subset of the hotspot regions, thereby significantly reducing candidate PAX7-FOXO1−interacting genes (Table 2).
Senator McCain said free time would de-emphasize large contributions by reducing candidates dependence on fund-raising.
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