Sentence examples for reduce binding to from inspiring English sources

HIV gp120 binding to CCR5 is CD4-dependent, as antibody inhibition of CD4 can reduce binding to CCR5 by 87% (Trkola et al., 1996).

One strategy seeks to reduce binding to 11β-hydroxylase, a critical enzyme in the steroid biosynthetic pathway, which is potently inhibited by etomidate.

A corresponding mutation has been shown to strongly reduce binding to the HP1 chromoshadow domain of Sp100A and LBR [55].

The siDirect software minimizes nonspecific complementarity of siRNA sequences to reduce binding to unrelated sequences.

The humanized antibody was engineered into an IgG4 framework to reduce binding to Fcγ and C1q receptors and decrease risks of amyloid-related imaging abnormalities [ 219].

Whereas deletions in the coding sequence did not affect SRBF1 binding, deletions 1 4 (Δ1–Δ4, Figure 1C,E) abolish, or significantly reduce binding to the sqt1 probe.

JNK inhibition results in reduced expression of Bim and reduced binding to Mcl-1.

In particular, the NE-generated VEGF fragment (VEGFf) is unable to bind to VEGFR2 and shows reduced binding to heparin.

Compared to WT Rab2A, while either mut1 or mut2 markedly reduced binding to Erk, mutating both sequences completely abolished the ability of Rab2A to bind to Erk.

In contrast, 2F5 showed a reduced binding to proteoliposomes, suggesting that the 2F5 epitope was differently exposed in both contexts.

In vitro, these mutant DR3 molecules were resistant to DM-catalyzed CLIP release and showed reduced binding to DM.