Sentence examples for reduce affinity for from inspiring English sources

Alanine mutations at D31, D32 and K34 on the C strand and K43 and R48 on the C′ strand reduce affinity for CD58 by 47-127-fold as measured by isothermal titration calorimetry.

This has been shown to destabilize MBD structure and reduce affinity for methylated DNA (20).

It creates an unusually hydrophobic ligand-binding site and may reduce affinity for polar ligands like O2 [ 51].

Substituents on the purine 6-position larger than the natural exocyclic heteroatoms were shown to significantly reduce affinity for the hypoxanthine H2 transporter (19).

Both also are involved in third-order interactions, by which the amino acid changes further reduce affinity for the G3xT4 combination and increase affinity for the G3xA4 combination.

Other modifications, such as deglycosylation, that reduce affinity for FcγR and impair ability to bind complement can be shown in mice to reduce potential vascular side effects of anti-Aβ mAbs [ 35].

W430A had strongly reduced affinity for tetramethylammonium.

Several neurokinin NK1 receptor antagonists currently being developed for anxiety and depression have reduced affinity for the rat and mouse NK1 receptor compared with human.

A missense mutation in the G-box reduces affinity for the centriolar shuttling protein STIL and causes primary microcephaly.

We first confirmed, using in-vitro binding studies, that all five NK1 antagonists had comparable affinity for gerbil and human NK1 receptors, and reduced affinity for the rat NK1 receptor.

Interestingly, the N-terminal LRP5 gain-of-function mutations (e.g. G171V) show reduced affinity for Dkk1, and thus presumably are due to Lrp5 derepression (Boyden et al., 2002; Ai et al., 2005).