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Some mutations are in the active site, directly disrupting binding and catalysis, but many are far from the active site and reduce activity by destabilising the protein structure, or affecting correct oligomerisation.
Carbon (coking) formation is also possible for this process and will block access to active sites and thus reduce activity.
The relaxation response may activate genes associated with dilating the blood vessels and reduce activity of genes associated with blood vessel narrowing and inflammation.
(c Need to halt or reduce activity not a defense.
Higher marginal tax rates distort behaviour and reduce activity".
Conversely, effort may reduce activity in task-specific regions and the default-mode network23,25,26.
The series was optimized to reduce activity on D2 receptor.
Normally, small reptiles tend to reduce activity during such an environmental onslaught to avoid becoming dehydrated.
A bad first-moment shock will reduce activity across the board.
Our strategy is to use low frequency TMS to reduce activity of brain areas appearing to generate voices.
Such proactive flow management can help field managers improve flow readiness, which should reduce activity delays and improve schedule conformance.
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CEO of Professional Science Editing for Scientists @ prosciediting.com