Albracht and Arampatzis [202] indicated that increased tendon stiffness is indicative of greater energy storage and return and a redistribution of muscular output within the lower extremities while running, which might result in improved RE.
The mechanism highlighted by our data is that besides its strong influence on CaO2, rhEpo was found to enhance leg V̇O2max in normoxia through a preferential redistribution of cardiac output toward the exercising legs, whereas this advantageous effect disappeared during severe hypoxia, leaving augmented CaO2 alone insufficient for improving peak leg O2 delivery and V̇O2.
In this regard, NBO-induced redistribution of cardiac output to the hepatosplanchnic regions was recently reported in a pig model of severe sepsis [ 36].
Moreover, a decrease in the whole body oxygen consumption under hyperoxia has been reported in critically ill patients [ 3], and animal studies also noted that hyperoxia could result in the redistribution of cardiac output [ 4].
The incidence of asphyxia is estimated at between 1 and 10 per 1,000 live births and these patients are prone to multiorgan dysfunction and a redistribution of cardiac output to maintain cerebral, cardiac, and adrenal perfusion, while potentially leading to renal ischemia.
The cerebroplacental ratio quantifies the redistribution of the cardiac output resulting in a brain-sparing effect.
The effects of X-radiation on the Nembutal-induced redistribution of the cardiac output in two types of transplanted mouse tumours and some normal mouse tissues have been investigated, using rubidium-86 and 125I-human serum albumin.
The increase in femoral vascular resistance is an important index of this fetal cardiovascular strategy as it not only decreases oxygen consumption by the hindlimbs but it also contributes to the redistribution of the cardiac output away from peripheral circulations (7, 25).
However, mild hypoperfusion with increased hepatic oxygen extraction rate and redistribution of the global cardiac output to other organ systems than the hepatic system has been reported by several investigators [ 12, 20].
Activation of the chemosensitive CB-AM axis leads to adaptive hyperventilation and increased cardiac output with redistribution of blood flow to the most O2-demanding organs, such as the brain or the heart.
