One way full employment can be assured is to redistribute the aggregate of work in the economy to all workers by reducing the length of the individual workday to create job vacancies.
Nevertheless, in pathological conditions such as amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD), TDP-43 appears in the form of large insoluble protein aggregates redistributed within the cytoplasm [5].
E-cadherin was redistributed into cytoplasmic aggregates in blastomeres and dramatically redistributed in the extraembryonic yolk cell.
Fodrin was redistributed to form intracellular aggregates, which were located in membrane blebs, an indication that it may serve as an important substrate for SigA during the course of human infection.
As expected, this redistribution relies on LRRK2 Roc-COR-dishevelled interactions, since the full-length myc-tagged LRRK2 (Fig. 4A C) and the myc-tagged Roc-COR tandem domain (Fig. 4D F) both redistributed to FLAG-DVL1 aggregates.
Recent studies have shown that upon Fas stimulation, the Fas receptor forms an aggregate and is then redistributed to lipid rafts.
In keeping with these affinity purification results, in cells overexpressing Flag-TDP-12xQ/N the HSP70 factor was observed redistributed and co-localizing perfectly with the induced aggregates (Supplementary Material, Fig. S2).
During mitosis, ataxin-1 accumulations redistributed equally among daughter cells, in contrast to polyQ aggregates.
In contrast to the asymmetrically dividing polyQ aggregates, nuclear polyQ ataxin-1 accumulations are redistributed equally among the daughter cells.
We observed a partial co-localization of Sig-1R with aggregates in mutant huntingtin protein-expressing cells, suggesting that the Sig-1R may be redistributed or delocalized in these cells.
In addition, mitotic cells redistributed the nuclear accumulations of polyQ-expanded ataxin-1 proteins to both daughter cells, whereas 'true' polyQ aggregates were all trans-located to one daughter cell.
