If the parameter is a redirected, this returns the redirection string rather than what the redirection evaluates too.
When using transient RNA expression systems in clinical studies, multiple infusions with receptor-redirected T cells appear necessary.
The SARS-CoV-specific T-cell lines and HBV Core 18 27 TCR-redirected T-cells were obtained in previous studies 24, 25.
The goal of this study was to facilitate understanding of the redirected sensation by examining the sensory characteristics of the reinnervated skin through perceptions of objectively measured stimuli.
Building on previous protein engineering studies and guided by a structural model for the redirected power stroke of myosin VI, we have constructed bidirectional myosins through the rigid recombination of structural modules.
To understand if we are able to generate Half DVD-Ig molecules to study the effect of anti-CD3 binding valency on redirected T cell cytotoxicity for tumor killing in vitro, we generated a Half anti-EGFR (outer domain)/anti-CD3 (inner domain) DVD-Ig molecule connected using a long-long (L-L) linker by including four mutations at CH3 domain and two cysteine mutations at the hinge region (Fig. 2A).
Thus, using redirected trogocytosis, HEK-FcγRII cells provide a versatile cellular system to study the capture of overexpressed, fluorescent proteins by T or B cells and the capture of FcγRII can be used to control for trogocytosis efficiency.
Ongoing studies in our laboratory are aimed at generating TCR-redirected T cells that transiently express the recombinant TCR and are, thus, safer to control once infused in the patient [ 50].
The studies together suggest that inside the cell, up to 4.4 mM Fe2+ can be directed (redirected) to load β.
Importantly, the donor nerve target should be synergistic with the redirected target for the brain to accommodate the rewiring of the newly redirected fibers [ 53].
We have shown in clinical [40] and preclinical studies [51] that effector memory T cells make the largest contribution to BiTE activity, and that redirected T cells can lyse tumor cells independent of T cell receptor specificity, MHC class I expression and the need for costimulation [30], [34], [35].
