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Henschke et al. [ 18] conducted a large cohort study to determine the presence of serious pathology when red flags were identified in people with an acute episode of back pain; they found that red flags usually present a high false-positive rate and only a few red flags (prolonged use of corticosteroids, age >70 years and significant trauma) were predictive for detecting fractures.
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Where red flags are identified the person will be referred for further investigation.
If any "red flags" are identified, indicating serious pathology, the patients will be referred appropriately and excluded from the study.
Those patients in which such "red flags" are identified are referred to surgery or to the appropriate diagnostic procedures.
Key recommendations in evidence-based clinical practice guidelines include patients staying active and avoiding bed rest, trying paracetamol as the first choice of analgesic, and general practitioners (GPs) providing education, reassurance of likely positive prognosis, and not routinely ordering radiological examinations unless 'red flags' are identified [ 2- 4].
In retrospect, red flags were flying.
The red flags were there.
Read how other red flags were ignored.
To avoid missing these cases, some headache characteristics (red flags) have been identified [1].
As Marriott's example suggests, identifying red flags is essential to M&A due-diligence success.
The real red flags are found within.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com