To determine whether such epigenetic alterations were responsible for the enhanced growth characteristics of the RB-deficient p53DD, recurred cell population, cell growth was examined after 5 days of 5-aza-dC treatment.
Interestingly, RB-deficient p53DD cells that have recovered from an initial treatment of CDDP were more resistant to a second treatment, as compared to all other cell lines (Figure 6A), and the ability of the RB-deficient p53DD, recurred cell population to continue proliferating post-CDDP treatment was enhanced (Figure 6B).
A shortage of and erratic nature of rainfall, frequently recurring droughts, and population growth are the main constraints affecting crop production in the study area.
Managers of forest wildlife populations make recurring management decisions based on incomplete knowledge of system states.
Direct lethal and sublethal effects of pesticides on farmland birds' populations are recurring questions and largely debated.
A general lack of IBD, at a regional scale to the west of the CMR, is typically considered to be the result of a large, stable population with historically recurring gene flow, which was further supported by the high migration rates among both populations and regions.
A prescription register survey in Denmark revealed that nearly 1% of the population recurred to sumatriptan in 1-year period [7].
Strain-focussed studies could also identify how many distinct HRVs circulate in a single respiratory season, how often a given strain recurs in a population and just how many HRV strains there are.
In comparison to ER−, the ER+ population recurs later [ 1], and this was also the case in our study.
Most of these CNVs have been identified because they recur in the population, either as relatively large events implicating many genes and arising from nonallelic homologous recombination (NAHR), or through the accumulation of different, generally de novo mutations at a single locus (e.g. NRXN1, VIPR2).
