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Recurring Gains?
Even the bluest of the blue-chips, IBM, hasn't been able to resist the call of the wild ledger (see: "Recurring Gains?").
The highest frequency of recurring gains (62%) was noted at 5p13.33 that contained TERT and CLPTM1L.
Cluster A1 was characterized by few aberrations, which comprised recurring gains on 5p, 7p, 14q and 20q, and losses on 8p (Table S2).
Fluorescent in situ hybridization (FISH) analysis of four genes, E2F8, ETV4, EZH2 and FAM84B, which show the most recurring gains, revealed remarkably complex mixtures with varying gains and number of subclones.
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Of all the selected loci, 5p15.33 containing TERT (telomerase reverse transcriptase isoform 2) showed the highest frequency of recurring gain regardless of ALK fusion.
With large variation in overall genomic instability, recurring genomic gains and losses were prominent.
Recurring allelic gains and losses on 14 chromosome arms have been detected in more than 30% of HCC cases [ 9- 11].
No statistically significant overlap with genes was observed with the breakpoints of recurring genomic gains (p value 0.9997) (see also Figure 5D), or with rearrangements in wild-type cells (p value 0.621).
We found three frameshift mutations and one stop-gain mutation in BRCA2; two stop-gain mutations in ATM; a recurring stop-gain mutation in BRIP1 affecting two families and two frameshift mutations in CHEK2.
Even outside of government bills, the Prime Minister's support of Canada's action has been a recurring topic, gaining him both supporters and critics among the Canadian population.
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