Among a set of observed relevant DNA sequences coming from a set of co-regulated genes, there exist some short, functional yet hidden sub-sequence patterns which recurrently appear across genomic sequences.
For each interval, aberrations recurrently appear in columns randomly sampled with rate rc.
For each interval, aberrations recurrently appear in columns randomly sampled with rate r c.
Two species recurrently appeared important: the woolly monkey and white lipped peccary.
The problem to be addressed is to statistically test whether a genomic aberration recurrently appears at each position.
However, not all M1c lineages present this mutation that, in addition, recurrently appears in a M1b1 lineage.
Four hormone genes (GH, PRL, LHB, and FSHB) recurrently appeared in all the six sequencing libraries with extremely high expression levels.
However, leaving apart a number of genes that recurrently appear as being under selection from the different studies, there are large differences in the specific lists of candidate genes being reported by the different studies.
> To further characterize the unique gene expression profile in the pituitary, we included 61 genes that recurrently appeared in the top 100 most highly transcribed genes of each sample, and then grouped them into five categories in terms of their functions (Supplementary Table S3).
Among them, alterations in NOTCH1, SF3B1, BIRC3, ATM, and MYD88 were recurrently found, appearing in 3 15% of CLL patients, either combined or as solely lesions [ 25, 26, 117, 118].
This problem appears recurrently in reverse engineering, where a set of (possibly massive and noisy) data points obtained by 3D laser scanning have to be fitted to a free-form parametric curve (typically a B-spline).
