Depressive episodes in winter depression are highly recurrent and appear to be clearly endogenous as there is no psychosocial factor that would account for their onset.
In the validation data (n = 1,195), 307 (25.69%) developed recurrent major depression over the follow-up period.
In the development data (n = 1,518), 382 (25.16%) developed recurrent major depression since wave 1.
About four years ago, I was diagnosed with recurrent major depression and prescribed Prozac.
The unipolar and control samples used as comparison groups have previously been described in Farmer et al. In brief, participants meeting DSM-IV and ICD-10 criteria for recurrent major depression (unipolar depression: n = 1737) were recruited and assessed (as part of the Depression Case Control DeCC study) using the procedures and assessments described above for the bipolar sample.
Since its inception, it has been shown to be efficacious in several landmark psychotherapy trials, including the NIMH Treatment of Depression Collaborative Research Program and the Pittsburgh Maintenance Study of recurrent major depression (Elkin et al., 1989; Frank et al., 1990; Markowitz, 1998; Weissman & Markowitz, 1994).
The comparative efficacy of lithium and amitriptyline in the maintenance treatment of recurrent unipolar depression was investigated by Greil et al. (1996) in a RCT with 81 patients over a treatment period of 2.5 years.
Hippocampal atrophy in recurrent major depression.
Furthermore, most cases of recurrent adult depression have their initial onset during adolescence.
BD minor: dysthymia, minor depression, or recurrent brief depression associated with (a) hypomanic syndrome or (b) hypomanic symptoms 4.
BD minor: dysthymia, minor depression, or recurrent brief depression associated with (a) hypomanic syndrome or (b) hypomanic symptoms.
