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If several acute attacks occur within a year, it's called "recurrent". Treatment begins with simple remedies, such as nasal irrigation (see the box above) and if necessary progresses to more advanced strategies, such as prescription drug therapy or surgery.
Despite the surface difficulties with the Los Angeles gang-war story, scene after scene in "Brother" bear Mr. Kitano's signature: yakuza vignettes, particularly those shot in Tokyo, that achieve a Scorsese-like feel of authenticity; the recurrent treatment of the issues of honor and loyalty (and their constant companion, betrayal); suicide and self-sacrifice.
The need for recurrent treatment is therefore not unexpected.
The infertility crisis may be ongoing or chronic after recurrent treatment failure.
Of those showing these sub-optimal therapeutic responses, Stimpson [ 4] estimated that a minimum of 30% of patients experience recurrent treatment failures.
Non-steroidal aromatase inhibitors (nsAIs), such as anastrozole and letrozole, have been mainly employed as early recurrent treatment for postmenopausal breast cancer [ 2, 3].
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Recurrent treatment-induced brain swelling, a veritable cocktail of seizure and cancer meds, and tumor progression all took their toll.
Although AAV-mediated exon skipping was shown safe and efficient to rescue a truncated dystrophin, it appears that recurrent treatments would be required to maintain therapeutic benefit ahead of the progression of the disease.
CONCLUSION: These results suggest that patients with chronic or recurrent, treatment-resistant depression may show long-term benefit when treated with VNS.
We report three cases with differing manifestations of IgG4-associated ocular and orbital inflammation: a case of recurrent, treatment-refractory sclero-uveitis that was diagnosed as granulomatosis with polyangiitis with an IgG4-related component, a case of pachymeningitis with optic neuritis that resulted in permanent visual loss, and a case of orbital inflammatory pseudotumor.
In a recent randomized phase II trial involving patients with stage IIIB, IV, or recurrent, treatment-naïve NSCLC, addition of an anti-IGF-1R antibody (CP-751,871; Pfizer) to standard chemotherapy (paclitaxel and carboplatin) led to a 46% objective response rate versus a 32% rate in patients receiving chemotherapy alone [12].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com