Sentence examples for recurrent transcript from inspiring English sources

Interestingly, the only identified recurrent transcript that encoded a fusion protein SLC45A3 ELK4 was not the result of genomic alteration, but apparently the result of a read-through transcription.

To further highlight the clinical significance of the genes mapping to recurrent copy number altered regions in gastric cancers as well as to validate the microarray results, eleven genes were selected for the affinity capture based transcript analysis (TRAC assay).

Both recurrent fusion transcripts associated with breast cancer involved membrane proteins, which raises the exciting possibility that they are breast cancer-specific cell surface markers that could be targeted with antibody drug conjugates.

Tomlins et al. [ 51] first reported the occurrence of a recurrent TMPRSS2 ERG fusion transcript (transmembrane protease serine 2 gene fusion with E twenty-six (Etranscriptiontion factors) in those with prostate tumors.

Recurrent read-through transcripts have not yet been characterized in breast cancer.

Second, different Meis genes have undergone recurrent truncation at the transcript and genomic level.

Comparing gene transcript levels between recurrent and non-recurrent cervical cancer patients revealed significant differences (P=0.038) in transcript levels for the angiogenesis inhibitor TSP-2, with the highest levels in non-recurrent cases.

From the analyses of the transcripts, 20 recurrent themes became apparent.

To our knowledge, this is the first report characterizing recurrent read-through fusion transcripts associated with breast cancer.

We discovered two recurrent read-through fusion transcripts that were identified in breast cancer cell lines, confirmed across breast cancer primary tumors, and were not detected in normal tissues (SCNN1A- TNFRSF1A and CTSD- IFITM10).

We used paired-end RNA-seq to identify two novel recurrent read-through fusion transcripts associated with breast cancer, and we used genomic DNA sequencing, qPCR, cDNA clone sequencing, small interfering RNA (siRNA) knockdown, and Western blots to further confirm and characterize these fusion transcripts.