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Consistent with previous reports, among the overall cohort, we found a 43.2 % rate of any discordance between ER, PR, and HER2 receptor status in primary and recurrent research biopsies.
Receptor status between primary cancer and recurrent research biopsies differed in 43.2 % of patients with available data (18.8 % among patients who underwent the research biopsy before any systemic treatment, 48.1 % after treatment).
Among patients with data from paired samples, (primary and recurrent research biopsies), agreement (yes or no) between ER, PR, and HER2 status was tabulated and inter-rater agreement between ER, PR, and HER2 was calculated [simple kappa coefficients and asymptotic standard error (ASE)].
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Analysing the process by which students whether at university or not manage and facilitate their own learning has been a recurrent educational research problem.
Within recurrent miscarriage research supportive care demonstrated beneficial pregnancy outcomes in early pregnancy.
In the setting of recurrent events, research studies commonly count only the first occurrence of an outcome in a subject.
The interrelated nature of treatment processes and outcomes and the variable and often long timeframe of change are becoming recurrent themes in research papers in these areas [ 14- 18].
Emphasis on educational attainment in childhood as a barrier to PA is a recurrent theme in research with particular ethnic minority groups (e.g., Chinese [ 48], Middle Eastern [ 11], Bangladeshi, Pakistani and Black African [ 17] populations) living in Western countries.
Given the increasing availability of complete genome sequences, these analyses are increasingly possible, and as with replicates in experimental research, recurrent events will help us to sketch an increasingly focused picture of genome evolution.
A recurrent observation in our research, however, is that network companies are not always capable to acknowledge or recognize dilemmas.
A recent development is an application to the UK Human Fertilisation and Embryology Authority HFEAA) for a licence to use germ line genome editing for research into recurrent miscarriage (Cressey et al., 2015).
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