A radiometric rule was suggested in which oncogene candidates should be affected at a recurrent position by at least 20% of missense mutations [ 25].
For recurrent alterations in positions with low frequency SNPs or without reported SNPs, Sanger sequencing was used in order to find or exclude genetic changes.
It is not unlikely that the rare T1'2'3 mtDNAs are indeed T1 or T3 mtDNAs that have reverted at their single diagnostic site (16113 and 16255, respectively), since multiple recurrent mutations at these positions are predicted by the T mtDNA tree [9].
A query requesting variants in the RD pocket revealed multiple kinases with recurrent variants at pocket positions (Table 1).
Results: Here, we present the heterogeneous hidden conditional random field, a new integrated array-CGH analysis method for jointly classifying tumors, inferring copy numbers and identifying clinically relevant positions in recurrent alteration regions.
Direct sequencing of the KCNJ5 gene revealed that all affected members in the four relatives not only had heterozygous mutations in KCNJ5, but all had mutations that altered the same amino acid, G151, which is one of the two positions showing recurrent somatic mutation in aldosterone-producing adenomas.
Radiological assessment showed that one uncemented socket in a revision arthroplasty performed for recurrent dislocation had changed position, but was stable in the new position.
One uncemented socket in the revision group performed for recurrent dislocation had changed position at the 6-month review, but was stable in the new position (Fig. 4a c).
The map was built using the same hierarchical mapping LOD thresholds as outlined above (LOD3, LOD2, LOD1 and most likely position) using recurrent executions of "build", "polish" and "flips".
Additionally, indels rarely occur in the same positions and the "recurrent" indels are hard to define.
