Although FOF and recurrent falls overlap, there seems to be a distinct and stronger association between fear of falling and PA than with falls history.
Recurrent regions overlapping centromeric and telomeric regions according to PennCNV definitions or containing less than five consecutive microarray probes were excluded.
On the other hand, 107 of the genes on the recurrent regions overlapped with V2 and they include TACC3, ECT2, CDC6, NOTCH1, and PIK3CA etc.
Nonetheless, we also find candidate tumor suppressor genes that overlap recurrent deletions.
In particular, 21 of the 23 RARs overlap recurrent copy number alterations identified in EBCs (stage I and II) from whites, blacks, and Hispanics by Thompson et al.'s recent study [ 15].
Inside recurrent regions, minimal overlapping regions (MOR) were identified as the smallest region of overlapping loss or gain.
Of note, the recurrent presence of overlapping sets of transcription factors at several enhancers of a particular gene locus may be one of the reasons that deletion of individual enhancer elements often causes only mild phenotypes.
For the clusters including recurrent trans-factors, the overlap was 21% on average.
KC-SMART profiles of mouse Brca1 Δ/Δ ;p53 Δ/Δ and Brca2 Δ/Δ ;p53 Δ/Δ mammary tumors showed that significantly recurrent genomic aberrations largely overlap with recurrent aberrations in p53 Δ/Δ tumors and that these common aberrations occur more frequently in Brca1 Δ/Δ ;p53 Δ/Δ and Brca2 Δ/Δ ;p53 Δ/Δ mammary tumor compared to the p53 Δ/Δ tumor group.
Apart from the two major targets mentioned above, seven additional segments showed recurrent (≥ 3 cases) overlapping amplifications; 1p34, 1q23, 2p25, 3p25, 10q22, 11q13, and 16p13 (Table 2).
