In patients treated for esophageal cancer at curative intent, distant recurrence and more than three recurrent locations were independent prognostic factors associated with worse post-recurrence survival, irrespective of primary tumor characteristics.
Distant recurrence and more than three recurrent locations were identified as independent prognostic factors associated with a worse post-recurrence survival, irrespective of primary tumor characteristics.
Distant recurrence and more than three recurrent locations were identified as independent factors associated with a worse survival, irrespective of primary tumor characteristics.
Nonetheless, most patients who were not eligible had advanced disease (i.e. distant recurrence or more than three recurrent locations), which reflects high dependency of the patient's condition on the site and number of recurrent tumors.
As such, extensions were proposed along with a scope for future work: Areas around highly recurrent locations where the mechanism reports uniformly, effectively stopping the privacy erosion.
Despite most of the trips taking place among 30% of their (recurrent) locations; we can only predict the occurrence of an exploration with at best 41% of accuracy.
The survival of patients with more than three recurrent locations was extremely poor, with a median survival of 2.0 months after the diagnosis of recurrence compared with 6.0 months in patients with a solitary recurrence.
The primary tumor regions P3-P5-P4 are the most closely related to the recurrences, with an ancestor tumor subpopulation that would give rise to these primary regions, both intra-pelvic recurrent locations and most of the extra-pelvic (ER1, ER2 and ER4).
Other artifacts, such as over-replicated loci ('pileups'), as previously reported in WGA [ 40, 42, 43], do occur, but they are not at recurrent locations in different cells, and are sufficiently randomly distributed and sparse so as not to affect counting over the breadth of a bin, when the mean interval size is 50 kb.
Multivariable analysis identified distant recurrence as opposed to locoregional recurrence [hazard ratio (HR) 2.15, 95%% confidence interval (CI) 1.27 3.65; p = 0.005], more than three recurrent locations (HR 2.42, 95 % CI 1.34 4.34; p = 0.003), and treatment (HR 0.29, 95 % CI 0.20 0.44; p < 0.001) as independent prognostic factors associated with post-recurrence survival.
