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CNVs chosen for study were recurrent, identified in controls, and significantly enriched in cases (Table 1 ).
Even if we combine all available data regarding APC mutations in Greek families, only three more mutations are recurrent (identified also in two families) in a total of thirty different mutations.
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This underscores the importance of smoking cessation in reducing CVD and suggests that a history of preterm delivery (especially if severe, indicated or recurrent) identifies women who could be targeted for CVD screening and preventative therapies.
Genes affected by copy number abnormalities comprised of recurrent CNAs identified from PCGP, and genes with known amplification (n = 16) or deletion (n = 38) identified by Cancer Gene Census.
The novel region of recurrent amplification identified at 8q24.33 q24.23 formed the focus of our further investigations.
Of the 41 minimal recurrent regions identified in the tumour samples, 24 represented gains and 17 losses of chromosomal segments.
The minimal recurrent region identified here was 10q25.3-q26.11, and frequent loss of 10q25 has also been previously reported in MFHs [6].
A semi-structured question script was derived to pursue recurrent patterns identified in the observational data.
The histology-specific mRNA and miRNAs were defined as recurrent findings, identified in 2 or more independent studies.
Of the patients randomised to the 'Aggressive' arm 83 (77%) had recurrent cancer identified and 62 (57%) patients had 'second-look' surgery.
Patients with recurrent events were identified as such by death, myocardial infarction, or hospitalization for recurrent ACS.
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