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Recent advances in molecular genomic analyses of lung adenocarcinoma specimens have revealed recurrent association of distinct gene mutations or fusions with particular clinicopathological entities [ 3].
One conspicuous feature concerning the role of IDH in human is a recurrent association with brain cancers and leukemia (Kranendijk et al. 2010; Tonjes et al. 2013) which has been associated with the accumulation of 2-hydroxyglutarate.
Indeed, the recurrent association of both AID* and sA3G* MELs with regions enriched for the basal transcription machinery and in particular Spt16 -a chromatin chaperon associated with highly transcribed genes (Formosa, 2013), reinforces the idea that active transcription and potential pausing (at promoters highly dependent on the FACT/Spt16 complex) determines the deaminases targeting.
A total of 96 of the EST clones identified here matched with 26 accessions or genes that were also described by Derome et al. [ 20] and St-Cyr et al. [ 22] [see Additional file 3] who found a recurrent association of divergence in gene expression and parallel adaptive differentiation in multiple lakes (including Cliff lake) for these genes.
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Recurrent associations of autoimmune diseases in family members of patients have been reported.
Notably, there were also new recurrent associations inferred only by our method.
Despite the differences in study quality and heterogeneity of measured socio-economic variables, there have been some recurrent associations.
Learning results from multiple associations between simultaneous and consecutive sensor stimuli and is performed by a Dynamical Recurrent Associative Memory Architecture.
A recurrent theme among association members is frustration with players who overrate themselves.
For recurrent inversions, the association between phenotype and genotype is more obvious, and a number of such loci have been described.
A bevacizumab combination regimen was first evaluated in recurrent GBM in association with irinotecan in either prospective phase II or retrospective studies that showed encouraging response rates and relevant clinical benefit (CB) [ 9, 11, 12, 15, 16].
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