Sentence examples for recurrent alterations of from inspiring English sources

Posterior uveal melanomas have recurrent alterations of chromosomes 1, 3, 6 and 8.

Recent landmark next-generation sequencing campaigns of large cancer patient cohorts repeatedly revealed recurrent alterations of genes involved in epigenetic mechanisms [ 20, 23, 24, 59– 61].

The novel c.5763dupT mutation, which appeared in two unrelated families, was the only recurrent alteration of the BRCA2 gene identified in this study.

On the contrary, the mutation c.5763dupT, the only recurrent alteration of the BRCA2 gene identified in our study, was not found in Moravia.

The c.5763dupT mutation, which causes a premature termination of translation at codon 1923, appeared in two families and was the only recurrent alteration of the BRCA2 gene identified in this study.

We have focused this section on the detection of recurrent alterations since it is the aim of many CN analysis.

Heterogeneous copy number profiles with a high frequency of recurrent regions of amplification and frequent combinations of recurrent alterations (such as chromosome 8p loss, 8q gain, 16q loss, 17q and/or 20q amplifications) observed in the IMPC group prompted us to search for genomic subsets.

The boundaries of amplicons/deletions did not correspond to known germline CNVs (reported in the Database of Genomic Variants), and, for the subset of recurrent alterations, finding distinct boundaries in different cell lines was more consistent with somatic alteration.

The status representation has strong advantages over the log ratio as it reduces the complexity of the data, provides the scientist with a direct identification of abormalities and allows the straightforwad detection of recurrent alterations.

While some potential driver genes could be rapidly identified from this data due to their location on focal alterations, the majority of recurrent alterations are large and encompass numerous genes.

We have used mbanding-FISH to search for regions of recurrent alterations in breast tumour cell lines on five chromosomes.