In case of the LEE this may be the result of a recurrent loss and acquisition of genes (patchwork model), or of a loss of parts of the locus by deletion events subsequent to its primary acquisition as an entity [49].
The acquisition of recurrent chromosomal gains and losses during the progression from high-grade adenomas to invasive carcinomas is found in CRC tumors [10].
There are also cases of convergent gene acquisitions or recurrent transfers of the same genes.
These recurrent events suggested that the acquisition of avian PB1 segment might pose biological advantages to the reassorted viruses.
Indeed, by monitoring CTCs the acquisition of the recurrent T790M-EGFR drug resistance mutation became evident and coincided with the development of clinically refractory disease [ 55].
This results in the clonal acquisition of many recurrent abnormalities, such as gains of 1q and 8q and losses of 17p, and considerable divergence among subclones of the cancer in their large-scale chromosomal composition.
Populations with endemic cholera presumably have high levels of preexisting immunity following age-related acquisition patterns because of recurrent cholera exposures.
40 Similarly, in isolated del 5q -MDS the acquisition of del 5q -MDSceded diverse recurrentheriver mutacquisition
Approaches that aim to restore a woman's "healthy" vaginal microbiome and maintain homeostasis are much needed to prevent recurrent BV and its sequelae, including transmission and acquisition of HIV and adverse obstetric outcomes, such as preterm birth.
Balmford et al. [44] found that land acquisition costs are closely related to annual recurrent management costs [national mean land acquisition costs km−2 were 50.6±13.5 (mean±SE) times national mean recurrent costs km−2 y−1].
