There were no significant differences in gender, mentality, seizure type, and etiology between the recurrence and non-recurrence subjects in either treatment or control group (Table 2).
For analysis of recurrence, 794 subjects were evaluable (391 treated with fidaxomicin and 403 treated with vancomycin).
In order to clarify the relationship between age and recurrence, these subjects were categorized into two age groups to differentiate the recurrence rate.
In the case of death prior to recurrence, a subject was censored for RPFT at the last known date recurrence-free.
The hazard of the jth recurrence of subject i at time t is The other model resets the clock at every recurrence and is called the gap time model (PWP-G model).
The hazard of the jth recurrence of subject i at time t is In this model, each recurrence is modeled as a separate stratum, and each subject appears in all of the strata so that no assumptions are made with respect to the recurrence process.
Assigning t j -1 as the time at which the (j-1 th j-1 thoccurs, theventard occurs jtherecurrence of subject i at time t is Althazardthe PWP mofel makes the interpretation easy, the sizes of the risk sets become relatively small as the number of events increases, making the estimates unstable.
This overdispersion affects calculation of tail probabilities: for example, the probability of two or fewer recurrences in 24 subjects, each with recurrence probability 0.26, is 0.0034.
JSR and WBK participated in acquisition of recurrence data in study subjects and coordinated the study.
NW, KS, TM and KI participated in acquisition of recurrence data in study subjects and coordinated the study.
A higher number of known than novel CNVs showed recurrence in the subjects tested (7/8 recurrent clones were previously described -Table 1).
